The story takes place at Opequonsett High School, where nobody gives attention to arts, only to sports. Five freshmen who seem to have nothing in common at first meet in detention. Together, they form the most influential band in history, Lemonade Mouth. Olivia is a shy, isolated girl who leads the front vocals for the band. Wen is a laid-back, funny and care-free boy who plays the trumpet for the band. Stella, a loud, hyper firecracker originally from Arizona, plays an electric ukulele in the band. Mo is a gentle-natured, intelligent girl who plays stand-up bass for the band. Charlie, who has a gentle and shy nature, plays the congas, bongos and timbales for the band. The story is narrated by each of the five band members, their friends, fans, and some of their enemies; it is compiled by OHS "scene queen" Naomi Fishmeier.